Effect of Decompressive Craniectomy and Hypothermia on the Expression of c-Fos and Heat Shock Proteins Following Fluid Percussion Brain Injury in the Rat
نویسنده
چکیده
FPI model treated with hypothermia 9) , an association between Corresponding Author: Young-Min Han, M.D. Department of Neurosugery, Our Lady of Mercy Hospital, 665 Bupyung-Dong, Bupyung-Gu, Incheon, 403-720 Korea Tel: 82-32-510-5515, Fax: 82-32-511-2370 E-mail: [email protected] Effect of Decompressive Craniectomy and Hypothermia on the Expression of c-Fos and Heat Shock Proteins Following Fluid Percussion Brain Injury in the Rat
منابع مشابه
Delayed combination therapy of local brain hypothermia and decompressive craniectomy on acute stroke outcome in rat
Objective(s):Hypothermia and decompressive craniectomy (DC) have been shown to be neuroprotective. This study was designed to evaluate neuroprotective effects of delayed singular or combination of DC and local hypothermia on stroke. Materials and Methods: Cerebral ischemia was induced in 48 Wistar rats assigned to 4 groups: control, decompressive craniectomy (DC), local hypothermia (LH), combin...
متن کاملRegional induction of c-fos and heat shock protein-72 mRNA following fluid-percussion brain injury in the rat.
To evaluate the cellular response to traumatic brain injury, the expression of mRNA for c-fos and the 72-kDa heat shock protein (hsp72) was determined using in situ hybridization following lateral fluid-percussion injury (2.2-2.4 atm) in rat brain. At 2 h after injury, induction of c-fos mRNA was observed throughout the cortex ipsilateral to the site of injury, while increased expression of hsp...
متن کاملEffect of decompressive craniectomy on aquaporin-4 expression after lateral fluid percussion injury in rats.
Decompressive craniectomy is one therapeutic option for severe traumatic brain injury (TBI), and it has long been used for the treatment of patients with malignant post-traumatic brain edema. A lack of definitive evidence, however, prevents physicians from drawing any conclusions about the effects of decompressive craniectomy for the treatment of TBI. Therefore, the aim of the present study was...
متن کاملاثر محافظتی درمان ترکیبی با هیپوترمی موضعی مغز و کرانیکتومی بر مدل سکته مغزی
Background and purpose: Both hypothermia and Decompressive craniectomy (DC) have been shown to reduce ischemic injury in experimental middle cerebral artery occlusion (MCAO). This study was designed to evaluate the effect of delayed combination of DC and Local Hypothermia (LH) on infarct size, neurological outcome and blood brain barrier (BBB) disruption in a rat model of stroke. Material a...
متن کاملDecompressive Craniectomy in Traumatic Brain Injury:Factors Influencing Prognosis and Outcome
Background and Aim: Decompressive craniectomy can be life-saving for patients with severe traumatic brain injury, but many questions about its ideal application, indications, timing, technique, and even the definition of success of decompressive craniectomy remains unclear. The aim of this study was to assess the factors associated with prognosis and outcome of patients with traumatic brain inj...
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